The Neuroimaging Research Unit (NRU) has been and is currently involved in several research projects aimed at improving, using structural and functional magnetic resonance imaging (MRI)-based techniques, our understanding of the mechanisms leading to the accumulation of irreversible physical disability and cognitive impairment in many neurological conditions, including multiple sclerosis [MS] and allied white matter diseases, Alzheimer's disease and other neurodegenerative conditions, vascular disorders, and migraine.