The main interest of the laboratory is to understand the mechanisms that link the control of ribosome biogenesis and translation to cell growth. Ribosome biogenesis is a huge process that accounts for more than half of the transcriptional activity of cells. Hundreds of genes affecting ribosome biogenesis and translation are essential, yet their molecular function and regulation are obscure. From our discovery of p27BBP (alias eIF6)*, a gene necessary for the biogenesis of 60S ribosomal subunit, present from archaea to humans, we have been active in unveiling new pathways regulating ribosomal function.

In addition, our lab hosts a multidisciplinary environment in which basic cellular processes are analysed. Currently, we study the nuclear role of myosin isoforms, the proteomics of Ferroportin 1, and the relationships between adhesion to matrix and ribosomal biology.

*p27BBP=ß4 integrin Binding Protein; eIF6=Eukaryotic Initiation Factor 6. Sequence alignment of fruitfly, human, and yeast "p27".