The cancer cell is an outstanding model to unravel the rules governing physiology and pathology of the immune response. Clues on the immune response against cancer can be exploited to all fields of basic and clinical immunology. The research we are involved in finds its rationale on the evidence that spontaneous tumors are antigenic but poorly immunogenic. Main goals of our studies are to achieve a deeper understanding of the mechanisms underlying the scarce immunogenicity of cancer cells, and to identify means whereby induce an efficient tumor-specific immune response.