Our research is mainly focused on the basic cell biology of normal and malignant plasma cells, with implications for Ab responses and Multiple Myeloma (2% of all cancer deaths). The overall goal is to understand how plasma cells cope with proteotoxic stress to identify novel targets against plasma cell cancers. A strong background in bone cell biology and in vivo mouse studies, along with ongoing investigations on differentiation of osteoclasts, unique bone-resorbing cells, provides expertise and models to extend our studies to the myeloma bone marrow milieu.